Docetaxel Axios 80 mg/vial IV Infusion

Administer in a facility equipped to manage possible complications (e.g., anaphylaxis). Administer intravenously (IV) over 1 hr every 3 weeks. PVC equipment is not recommended. Use only a 21 gauge needle to withdraw docetaxel from the vial.

• BC locally advanced or metastatic: 60 mg/m² to 100 mg/m² single agent
• BC adjuvant: 75 mg/m² administered 1 hour after doxorubicin 50 mg/m² and cyclophosphamide 500 mg/m² every 3 weeks for 6 cycles
• NSCLC: after platinum therapy failure: 75 mg/m² single agent
• NSCLC: chemotherapy-naive: 75 mg/m² followed by cisplatin 75 mg/m²?
• HRPC: 75 mg/m2 with 5 mg prednisone twice a day continuously
• GC: 75 mg/m² followed by cisplatin 75 mg/m² (both on day 1 only) followed by fluorouracil 750 mg/m² per day as a 24-hr IV (days 1-5), starting at end of cisplatin infusion
• SCCHN: 75 mg/m² followed by cisplatin 75 mg/m² IV (day 1), followed by fluorouracil 750 mg/m² per day as a 24-hr IV (days 1?5), starting at end of cisplatinin fusion; for 4 cycles
• SCCHN: 75 mg/m² followed by cisplatin 100 mg/m² IV (day 1), followed by fluorouracil 1000 mg/m² per day as a 24-hr IV (days 1?4); for 3 cycles

For all patients:

• Premedicate with oral corticosteroids
• Adjust dose as needed